I pulled "Drawing the Sign" as my random basic weakness for Sefina in my circle undone campaign, and it really hurts! Drawing this during the upkeep phase when you have a hand full of cards is really frustrating (which is, I suppose, good for a weakness). This weakness has the potential to force a player to discard 5 cards at the end of the round (it's caused me to discard 9 over the past two scenarios)! Naturally, it'll hurt big-handed investigators like Safina and some Seekers. But, in contrast, it would be a pretty mild weakness for investigators that operate with few cards in-hand.

It's also hilarious thematically. Sefina is focusing on all of the spells and tricks that she can pull off for the objectives but then she gets completely distracted by drawing the sign and forgets most of what she had been thinking about.