Looks really bad to me. Two actions, 2 resources AND a non-boosted test on a specific enemy type to lock down a unit. Locking down a unit is essentially killing it, but probably a bit better since it doesn't go into the discard pile to recycle and come back. It has also has a bunch of niche uses like Trish Scarborough or Tommy Malloy that others have mentioned. On the flip side based on the FAQ, there are few, rare situations where the enemy can still hurt you while in play.

Surprisingly in faction I think this card is most similar to Monster Slayer. Both require a Strength test, and some resources to insta-kill an enemy. Handcuff requires an additional resource and action but costs 5 exp less. Unfortunately Monster Slayer (5) is pretty bad and I'm guessing probably never used. I'm thinking it might see more play around 2 exp.

I say this because Fang of Tyr'thrha exists at 4 exp. That essentially kills the enemy at any revealed AND lets you teleport, AND gives you stat boost. Out of faction, survivors have Dumb Luck which also removes an enemy from the board after a skill test with a generous margin and that only costs 2 exp.

If you look at Heroic Rescue vs. Heroic Rescue, for 2 exp you pay 1 less resource and can use it in adjacent locations (which I'll indirectly proxy as 1 action to move). Going from handcuff to a hypothetical 2 exp Monster Slayer, it has the same upgrade value, you would pay 1 less resource and use 1 less action.

Personally I'm not a fan of Handcuffs though, 2 actions to 2 resources to kill something seems way too slow and inefficient. I compare it to Spectral Razor which only takes 1 action, has an easier test, gives you a free engage and will kill most things already. Guardians likely have better ways to deal with enemies and only targeting humanoids (and non-elites) really makes it hard to slot into your deck if youre going in blind.

Not a fan of these cards that only target specific enemy types. I don't like having to memorize which campaign/scenario has what type of enemies, its more fun to go in blind.

This might've been more fun if it was able to target all enemy types, but is easier against humanoids (e.g. Strength test 4 vs non-humanoids, strength test 2 vs humanoids).

All in all, I think its not a great card anyways. Just take scene of the crime. Unless you're going solo, your guardian currently doesn't need to focus too much on clues (and gators like Carolyn Fern has other tools).

Even removing exhaust part away. this card would not even be close to broken.

might be wrong since I'm starting new with a new format but that's my bold opinion on this card so far.

The fact that this card trigger with Evade, Evade Action which is not a useful action or progressing action just multiplying how bad it is.

I'm about to build some deck base on this card but just realize it has to exhaust too so project closed.

"Non- symbol" mean things like , , , , , , , , ... and not any numbers. I believe you cannot re-roll numbers.

Unexpectedly handy for Jim Culver for fishing out . Didn't do probability math but 2 resets on Standard with Jim feels like it reliably allows you to pass test that you are equal or 1 higher as needed. Similar feeling to having Lucky! ready on hand but need to wear it first.

An enemy weakness that asks the question "why do mob goons cause horror?" Looking at the two elements, the effect and the discard condition, we get:

The effect: Daniela clearly has some history with these guys, and so she knows how do deal with them. About the only special thing about them is that direct damage effect, which turns off things like Bandages†, Guard Dog, Peter Sylvestre (2) as well as soak in general. The horror component of their attack is more worrying for Daniela, since she has less Sanity to use, but these bad boys aren't likely to get more than one hit in before she finishes them off, so it's not that significant. As hunters, this isn't an enemy weakness you can ignore, and Daniela isn't big on evasion, so the "mitigation strategy is doing 3 damage in one action. The obvious plan is to use Mechanic's Wrench to provoke an attack, then defeat them with Daniela's ability and a wrench attack. It's so obvious that it's a little odd that they don't have 4 health just to mess with it. If you'd rather not take an attack, many weapons + Vicious Blow will do the trick, as will Chainsaw. Brute Force might be the most direct solution, as Daniela would attack at 8 vs 3, making the 3 damage pretty likely to land, even without extra boosting. If you are worried, throw in an Overpower and get a card draw. I'd also like to endorse HanoverFist's janky solution, above. It's not efficient, but very satisfying if you can pull it off..

The discard condition: Beat them like rented mules.†† It's likely to take Daniella 1, maybe 2, actions to finish them.

Like most enemy weaknesses, this is below average, unlikely to end a scenario or campaign or, really, cost you more than one action.

† Thanks to Susumu, I realized that I meant Flesh Ward, not Bandages. Mea culpa.

†† Note: this should not be taken as an endorsement of beating mules, who are mostly hardworking and affectionate creatures.